Question about "Access denied"

I'm getting an "Access denied" message when I try to open my Endnote
file.  It seems to be a problem with the software.  Our IT people have
checked on their end.  
Has anyone had this problem before?
The only change recently with the program-I added some other users to
the list of authorized users, and we had a power failure last week.
Thanks for any help!
Carole